Synthetic circuit identifies subpopulations with sustained memory of DNA damage
نویسندگان
چکیده
منابع مشابه
Synthetic circuit identifies subpopulations with sustained memory of DNA damage.
Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopulations with heritable damage responses. Strongly responsive cells show multigenerational effects, inc...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369
DOI: 10.1101/gad.1994911